Cancer Vaccines: Antigen Selection Strategy
نویسندگان
چکیده
منابع مشابه
Antigen-Specific Cancer Vaccines
Advances in basic immunology over the past decade have changed the scope and application of cancer vaccines. Perhaps the most important advance is the demonstration that human tumors are immunogenic and the identification of tumor-specific antigens. In fact, dozens of immunogenic proteins have been identified in patients with cancer using high throughput technologies. More importantly, we have ...
متن کاملStrategies for cancer therapy using carcinoembryonic antigen vaccines.
Advances in molecular biology and immunology have renewed interest in the development of vaccines for the treatment or prevention of cancer. Research over the past 10 years has focused on the identification of suitable tumour antigens to use as targets for a variety of vaccine strategies. Carcinoembryonic antigen (CEA) was one of the first tumour antigens described, and is commonly expressed by...
متن کاملSANTAVAC ™: A Novel Universal Antigen Composition for Developing Cancer Vaccines
BACKGROUND Development of a universal cancer vaccine for the prevention of all cancers has been under development for many years. Antiangiogenic cancer vaccines elicit immune responses with the potential of destroying tumor vasculature endothelial cells without affecting vasculature integrity in normal tissues. The methods used in the development of antigen compositions comprising these vaccine...
متن کاملAllogeneic Antigen Composition for Preparing Universal Cancer Vaccines
Recently it was demonstrated that tumors induce specific changes to the surface of human endothelial cells thereby providing the basis for designing endothelial cell-based vaccines that directly target antigens expressed by the tumor endothelium. The present report extends these studies in vitro by investigating the efficacy of allogeneic antigens with regard to their ability to target immune r...
متن کاملStrain Selection for Generation of O-Antigen-Based Glycoconjugate Vaccines against Invasive Nontyphoidal Salmonella Disease
Nontyphoidal Salmonellae, principally S. Typhimurium and S. Enteritidis, are a major cause of invasive bloodstream infections in sub-Saharan Africa with no vaccine currently available. Conjugation of lipopolysaccharide O-antigen to a carrier protein constitutes a promising vaccination strategy. Here we describe a rational process to select the most appropriate isolates of Salmonella as source o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Vaccines
سال: 2021
ISSN: 2076-393X
DOI: 10.3390/vaccines9020085